Anti-EMC10 Polyclonal Antibody (HP872014)

Name: Anti-EMC10 Polyclonal Antibody
Brand: abinScience
SKU: HP872014
Price: 168 USD
Availability: InStock

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100ug

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Каталожный номер

HP872014

Описание

Anti-EMC10 Polyclonal Antibody (HP872014) is a rabbit polyclonal antibody detecting ER membrane protein complex subunit 10; Hematopoietic signal peptide-containing membrane domain-containing protein 1; EMC10; C19orf63; INM02; UNQ764/PRO1556 in ELISA, IHC, WB. Suitable for Human, Bovine, Rat, and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human EMC10 (Gly50-Pro190).

Цель

ER membrane protein complex subunit 10; Hematopoietic signal peptide-containing membrane domain-containing protein 1; EMC10; C19orf63; INM02; UNQ764/PRO1556

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

Q5UCC4, A1A4M2, Q6AYH6, Q3TAS6

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

ER membrane protein complex subunit 10 (EMC10) is a ~27 kDa protein. Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors.

1. Guna, A. et al. (2018) Science (New York, N.Y.) 359, 470-473. PMID: 29242231

2. Shurtleff, MJ. et al. (2018) eLife 7. PMID: 29809151

3. Chitwood, PJ. et al. (2018) Cell 175, 1507-1519.e16. PMID: 30415835

4. Pleiner, T. et al. (2020) Science (New York, N.Y.) 369, 433-436. PMID: 32439656

5. O'Donnell, JP. et al. (2020) eLife 9. PMID: 32459176

6. Reboll, MR. et al. (2017) Circulation 136, 1809-1823. PMID: 28931551

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-EMC10 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

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Anti-EMC10 Polyclonal Antibody (HP872014)

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