Anti-EP300 Polyclonal Antibody (HC510014)

Name: Anti-EP300 Polyclonal Antibody
Brand: abinScience
SKU: HC510014
Price: 168 USD
Availability: InStock

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概要
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概要

カタログ番号

HC510014

説明

Anti-EP300 Polyclonal Antibody (HC510014) is a rabbit polyclonal antibody detecting EP300 in ELISA, IHC, WB. Suitable for Mouse and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

種反応性

Human, Mouse

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human EP300 (His2283-His2414).

ターゲット

Histone crotonyltransferase p300, Protein lactyltransferas p300, Protein propionyltransferase p300, Histone acetyltransferase p300, Protein 2-hydroxyisobutyryltransferase p300, EP300, p300 HAT, Histone butyryltransferase p300, P300, E1A-associated protein p300

精製

Purified by antigen affinity column.

アクセッション番号

Q09472

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Histone acetyltransferase p300 (EP300) is a ~264 kDa protein. Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively).

1. Tropberger, P. et al. (2013) Cell 152, 859-72. PMID: 23415232

2. Delvecchio, M. et al. (2013) Nature structural & molecular biology 20, 1040-6. PMID: 23934153

3. Tian, Y. et al. (2025) Nature 641, 779-787. PMID: 40240600

4. Ogryzko, VV. et al. (1996) Cell 87, 953-9. PMID: 8945521

5. Jin, Q. et al. (2011) The EMBO journal 30, 249-62. PMID: 21131905

6. Hatzi, K. et al. (2013) Cell reports 4, 578-88. PMID: 23911289

8. Iioka, T. et al. (2003) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 18, 1419-29. PMID: 12929931

9. Yuan, ZL. et al. (2005) Science (New York, N.Y.) 307, 269-73. PMID: 15653507

10. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960

注意事項

For research use only.

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参考文献

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