

| Каталожный номер | HC510014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-EP300 Polyclonal Antibody (HC510014) is a rabbit polyclonal antibody detecting EP300 in ELISA, IHC, WB. Suitable for Mouse and Human.
Highlights
|
||||||||
| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human EP300 (His2283-His2414). | ||||||||
| Цель | Histone crotonyltransferase p300, Protein lactyltransferas p300, Protein propionyltransferase p300, Histone acetyltransferase p300, Protein 2-hydroxyisobutyryltransferase p300, EP300, p300 HAT, Histone butyryltransferase p300, P300, E1A-associated protein p300 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q09472 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
||||||||
| Информация об использовании продукта |
| ||||||||
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Histone acetyltransferase p300 (EP300) is a ~264 kDa protein. Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively). 1. Tropberger, P. et al. (2013) Cell 152, 859-72. PMID: 23415232 2. Delvecchio, M. et al. (2013) Nature structural & molecular biology 20, 1040-6. PMID: 23934153 3. Tian, Y. et al. (2025) Nature 641, 779-787. PMID: 40240600 4. Ogryzko, VV. et al. (1996) Cell 87, 953-9. PMID: 8945521 5. Jin, Q. et al. (2011) The EMBO journal 30, 249-62. PMID: 21131905 6. Hatzi, K. et al. (2013) Cell reports 4, 578-88. PMID: 23911289 8. Iioka, T. et al. (2003) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 18, 1419-29. PMID: 12929931 9. Yuan, ZL. et al. (2005) Science (New York, N.Y.) 307, 269-73. PMID: 15653507 10. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960 | ||||||||
| Примечание | For research use only. |



Свяжитесь с нами для индивидуальных предложений, оптовых запросов и других вопросов.
Почта: [email protected]
+86-027-65523339
Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China
中文
English
한국어
日本語
Español
Français
Русский