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| カタログ番号 | HB046014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-EPHA1 Polyclonal Antibody (HB046014) is a rabbit polyclonal antibody detecting EPHA1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human EPHA1 (Tyr599-Gly842). | ||||||||
| ターゲット | Tyrosine-protein kinase receptor EPH, EPHT1, Erythropoietin-producing hepatoma receptor, hEpha1, EPH, EPHA1, Ephrin type-A receptor 1, EPH tyrosine kinase 1, EPH tyrosine kinase, EPHT | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P21709 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ephrin type-A receptor 1 (EPHA1) is a ~108 kDa protein. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. | ||||||||
| 注意事項 | For research use only. |
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