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| カタログ番号 | HC008014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-EYA2 Polyclonal Antibody (HC008014) is a rabbit polyclonal antibody in ELISA, IHC, WB. Suitable for Human, Bovine, Mouse, and Chicken.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human EYA2 (Glu266-Leu538). | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00167, Q58DB6, O08575, Q9YHA0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein phosphatase EYA2 is a ~59 kDa protein. Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. 1. Fougerousse, F. et al. (2002) Journal of muscle research and cell motility 23, 255-64. PMID: 12500905 2. Patrick, AN. et al. (2013) Nature structural & molecular biology 20, 447-53. PMID: 23435380 3. Krishnan, N. et al. (2009) The Journal of biological chemistry 284, 16066-16070. PMID: 19351884 | ||||||||
| 注意事項 | For research use only |
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