Anti-F2/Prothrombin Polyclonal Antibody (HF621024)

Name: Anti-F2/Prothrombin Polyclonal Antibody
Brand: abinScience
SKU: HF621024
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HF621024

Description

Anti-F2/Prothrombin Polyclonal Antibody (HF621024) is a rabbit polyclonal antibody detecting Prothrombin in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human F2/Prothrombin (Thr328-Glu622).

Cible

F2, Coagulation factor II, Prothrombin

Purification

Purified by antigen affinity column.

Numéro d'accès

P00734

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Prothrombin (F2/PIVKA-II) is a ~70 kDa protein. Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells.

1. Naito, K. et al. (1991) The Journal of biological chemistry 266, 7353-8. PMID: 2019570

2. Choi, SH. et al. (2011) Blood 118, 6963-70. PMID: 21976677

3. Shinozawa, E. et al. (2018) Frontiers in pharmacology 9, 1431. PMID: 30568593

4. Senden, NH. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 161, 4318-24. PMID: 9780208

Note

For research use only.

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