

| Каталожный номер | HF621024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-F2/Prothrombin Polyclonal Antibody (HF621024) is a rabbit polyclonal antibody detecting Prothrombin in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human F2/Prothrombin (Thr328-Glu622). | ||||||||
| Цель | F2, Coagulation factor II, Prothrombin | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P00734 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Prothrombin (F2/PIVKA-II) is a ~70 kDa protein. Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells. 1. Naito, K. et al. (1991) The Journal of biological chemistry 266, 7353-8. PMID: 2019570 2. Choi, SH. et al. (2011) Blood 118, 6963-70. PMID: 21976677 3. Shinozawa, E. et al. (2018) Frontiers in pharmacology 9, 1431. PMID: 30568593 4. Senden, NH. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 161, 4318-24. PMID: 9780208 | ||||||||
| Примечание | For research use only. |




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