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| カタログ番号 | HC591014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-FADD Polyclonal Antibody (HC591014) is a rabbit polyclonal antibody detecting FADD in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FADD (Ser12-Glu206). | ||||||||
| ターゲット | Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, MORT1, FAS-associating death domain-containing protein, FAS-associated death domain protein, FADD, Protein FADD | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13158 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | FAS-associated death domain protein (FADD) is a ~23 kDa protein. Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. 1. Carrington, PE. et al. (2006) Molecular cell 22, 599-610. PMID: 16762833 2. Scott, FL. et al. (2009) Nature 457, 1019-22. PMID: 19118384 3. Wang, L. et al. (2010) Nature structural & molecular biology 17, 1324-9. PMID: 20935634 4. Li, S. et al. (2013) Nature 501, 242-6. PMID: 23955153 5. Pearson, JS. et al. (2013) Nature 501, 247-51. PMID: 24025841 6. Chinnaiyan, AM. et al. (1995) Cell 81, 505-12. PMID: 7538907 7. Medema, JP. et al. (1997) The EMBO journal 16, 2794-804. PMID: 9184224 | ||||||||
| 注意事項 | For research use only. |
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