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| カタログ番号 | HB329014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-FAHD1 Polyclonal Antibody (HB329014) is a rabbit polyclonal antibody detecting mitochondrial; OAA decarboxylase; ODx; 4.1.1.112; Acylpyruvase FAHD1; 3.7.1.5; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; YisK-like protein; FAHD1; C16orf36; YISKL in ELISA, IHC, WB. Suitable for Human, Bovine, Rat, and Mouse.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human FAHD1 (Ala25-Tyr221). | ||||||||
| ターゲット | Oxaloacetate decarboxylase, mitochondrial; OAA decarboxylase; ODx; 4.1.1.112; Acylpyruvase FAHD1; 3.7.1.5; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; YisK-like protein; FAHD1; C16orf36; YISKL | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6P587, Q2HJ98, Q6AYQ8, Q8R0F8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Oxaloacetate tautomerase FAHD1, mitochondrial is a ~24 kDa protein. Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition. Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle. Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Exhibits only a weak hydrolase activity on methylacetopyruvate and acetylacetone, and no activity toward acetoacetyl-CoA. 1. Zmuda, AJ. et al. (2024) Nature communications 15, 846. PMID: 38287013 2. Pircher, H. et al. (2015) The Journal of biological chemistry 290, 6755-62. PMID: 25575590 3. Weiss, AKH. et al. (2018) The Biochemical journal 475, 3561-3576. PMID: 30348641 4. Pircher, H. et al. (2011) The Journal of biological chemistry 286, 36500-8. PMID: 21878618 | ||||||||
| 注意事項 | For research use only |
Western blot analysis was performed using anti-FAHD1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: 293T cell lysate
Lane 2: Jurkat cell lysate
Lane 3: Mouse kidney lysate
Lane 4: Rat kidney lysate
Lane 5: Mouse liver lysate
Lane 6: Rat liver lysate
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