Anti-FCN1 Polyclonal Antibody (HT184014)

Name: Anti-FCN1 Polyclonal Antibody
Brand: abinScience
SKU: HT184014
Price: 96 USD
Availability: InStock

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Especificación:

20ug
50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HT184014

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human FCN1 (Gly130-Ala326).

Objetivo

Ficolin-alpha, FCNM, Ficolin-A, FCN1, Ficolin-1, Collagen/fibrinogen domain-containing protein 1, M-ficolin

Purificación

Purified by antigen affinity column.

Número de acceso

O00602

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Ficolin-1 (FCN1) is a ~35 kDa protein. Extracellular lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8.

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1. Liu, Y. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 3150-6. PMID: 16116205

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2. Garlatti, V. et al. (2007) The Journal of biological chemistry 282, 35814-20. PMID: 17897951

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3. Gout, E. et al. (2010) The Journal of biological chemistry 285, 6612-22. PMID: 20032467

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4. Honoré, C. et al. (2010) Journal of leukocyte biology 88, 145-58. PMID: 20400674

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5. Zhang, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 185, 6899-910. PMID: 21037097

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Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-FCN1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse liver lysate
Lane 2: Rat liver lysate