Anti-FCN1 Polyclonal Antibody (HT184014)

Name: Anti-FCN1 Polyclonal Antibody
Brand: abinScience
SKU: HT184014
Price: 96 USD
Availability: InStock

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HT184014

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human FCN1 (Gly130-Ala326).

Cible

Ficolin-alpha, FCNM, Ficolin-A, FCN1, Ficolin-1, Collagen/fibrinogen domain-containing protein 1, M-ficolin

Purification

Purified by antigen affinity column.

Numéro d'accès

O00602

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Ficolin-1 (FCN1) is a ~35 kDa protein. Extracellular lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8.

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1. Liu, Y. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 3150-6. PMID: 16116205

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2. Garlatti, V. et al. (2007) The Journal of biological chemistry 282, 35814-20. PMID: 17897951

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3. Gout, E. et al. (2010) The Journal of biological chemistry 285, 6612-22. PMID: 20032467

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4. Honoré, C. et al. (2010) Journal of leukocyte biology 88, 145-58. PMID: 20400674

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5. Zhang, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 185, 6899-910. PMID: 21037097

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Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-FCN1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse liver lysate
Lane 2: Rat liver lysate