

| Numéro de catalogue | HB249014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human FDXR (Ser33-Arg219). | ||||||||
| Cible | ADXR, Adrenodoxin reductase, NADPH:adrenodoxin oxidoreductase, mitochondrial, Ferredoxin reductase, Ferredoxin--NADP(+) reductase, FDXR, AR | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P22570 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) is a ~53 kDa protein. Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6. 1. Nicoll, CR. et al. (2024) Nature catalysis 7, 148-160. PMID: 38425362 | ||||||||
| Note | For research use only. |
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