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| カタログ番号 | HC679014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-FKBP5 Polyclonal Antibody (HC679014) is a rabbit polyclonal antibody detecting FKBP5 in ELISA, IHC, WB. Suitable for Human, Rat.
Highlights
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| 種反応性 | Human, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FKBP5 (Ser13-Lys252). | ||||||||
| ターゲット | AIG6, 51 kDa FKBP, FKBP51, FKBP54, Rotamase, Peptidyl-prolyl cis-trans isomerase FKBP5, FF1 antigen, 51 kDa FK506-binding protein, FKBP-51, Androgen-regulated protein 6, p54, PPIase FKBP5, 54 kDa progesterone receptor-associated immunophilin, HSP90-binding immunophilin, FKBP-5, FK506-binding protein 5, FKBP5 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13451 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Peptidyl-prolyl cis-trans isomerase FKBP5 is a ~51 kDa protein. Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production. 1. Pirkl, F. et al. (2001) Journal of molecular biology 308, 795-806. PMID: 11350175 2. Sinars, CR. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 868-73. PMID: 12538866 3. Yu, J. et al. (2017) Cell reports 18, 1229-1240. PMID: 28147277 4. Luo, K. et al. (2017) The EMBO journal 36, 1434-1446. PMID: 28363942 5. Romano, S. et al. (2015) Nucleic acids research 43, 6983-93. PMID: 26101251 6. DeDiego, ML. et al. (2019) Journal of virology 93. PMID: 31434731 | ||||||||
| 注意事項 | For research use only. |
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