Anti-FMO2 Polyclonal Antibody (HV250014)

Name: Anti-FMO2 Polyclonal Antibody
Brand: abinScience
SKU: HV250014
Price: 96 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HV250014

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human FMO2 (Gly295-Asn469).

Cible

FMO 1B1, FMO 2, Dimethylaniline monooxygenase [N-oxide-forming] 2, Pulmonary flavin-containing monooxygenase 2, Dimethylaniline oxidase 2, FMO2

Purification

Purified by antigen affinity column.

Numéro d'accès

Q99518

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Flavin-containing monooxygenase 2 (FMO2) is a ~60 kDa protein. Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation. Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid. In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate. Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton.

1. Henderson, MC. et al. (2004) Chemical research in toxicology 17, 633-40. PMID: 15144220

2. Henderson, MC. et al. (2004) Biochemical pharmacology 68, 959-67. PMID: 15294458

3. Henderson, MC. et al. (2008) Toxicology and applied pharmacology 233, 420-7. PMID: 18930751

4. Francois, AA. et al. (2009) Drug metabolism and disposition: the biological fate of chemicals 37, 178-86. PMID: 18948378

5. Dolphin, CT. et al. (1998) The Journal of biological chemistry 273, 30599-607. PMID: 9804831

Note

For research use only.

Images

Reférences

Fiche technique

Anti-FMO2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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