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| カタログ番号 | HV250014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FMO2 (Gly295-Asn469). | ||||||||
| ターゲット | FMO 1B1, FMO 2, Dimethylaniline monooxygenase [N-oxide-forming] 2, Pulmonary flavin-containing monooxygenase 2, Dimethylaniline oxidase 2, FMO2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q99518 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Flavin-containing monooxygenase 2 (FMO2) is a ~60 kDa protein. Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation. Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid. In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate. Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton. 1. Henderson, MC. et al. (2004) Chemical research in toxicology 17, 633-40. PMID: 15144220 2. Henderson, MC. et al. (2004) Biochemical pharmacology 68, 959-67. PMID: 15294458 3. Henderson, MC. et al. (2008) Toxicology and applied pharmacology 233, 420-7. PMID: 18930751 4. Francois, AA. et al. (2009) Drug metabolism and disposition: the biological fate of chemicals 37, 178-86. PMID: 18948378 5. Dolphin, CT. et al. (1998) The Journal of biological chemistry 273, 30599-607. PMID: 9804831 | ||||||||
| 注意事項 | For research use only. |
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