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Anti-FMO3 Polyclonal Antibody (HB603014)

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Vista general
Número de catálogoHB603014
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human FMO3 (Lys280-Thr532).
Objetivo Dimethylaniline oxidase 3, FMO form 2, Dimethylaniline monooxygenase [N-oxide-forming] 3, FMO3, FMO II, FMO 3, Trimethylamine monooxygenase, Hepatic flavin-containing monooxygenase 3
Purificación Purified by antigen affinity column.
Número de acceso P31513
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Flavin-containing monooxygenase 3 (FMO3) is a ~60 kDa protein. Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.

1. Rawden, HC. et al. (2000) British journal of clinical pharmacology 49, 313-22. PMID: 10759686
2. Perez-Paramo, YX. et al. (2019) Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 28, 311-320. PMID: 30381441
3. Veeravalli, S. et al. (2020) Drug metabolism and disposition: the biological fate of chemicals 48, 378-385. PMID: 32156684
4. Lang, DH. et al. (1998) Biochemical pharmacology 56, 1005-12. PMID: 9776311
5. Zhu, W. et al. (2018) Journal of thrombosis and haemostasis : JTH 16, 1857-1872. PMID: 29981269
Nota For research use only.
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Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-FMO3 Polyclonal Antibody

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