

| Numéro de catalogue | HV281014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-FN3K Polyclonal Antibody (HV281014) is a rabbit polyclonal antibody detecting FN3K in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human FN3K (Met1-Lys309). | ||||||||
| Cible | Protein-ribulosamine 3-kinase FN3K, Protein-psicosamine 3-kinase FN3K, FN3K, Fructosamine-3-kinase | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q9H479 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Fructosamine-3-kinase (FN3K) is a ~35 kDa protein. Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines. 1. Delpierre, G. et al. (2000) Diabetes 49, 1627-34. PMID: 11016445 2. Szwergold, BS. et al. (2001) Diabetes 50, 2139-47. PMID: 11522682 3. Delpierre, G. et al. (2002) The Biochemical journal 365, 801-8. PMID: 11975663 4. Collard, F. et al. (2003) Diabetes 52, 2888-95. PMID: 14633848 | ||||||||
| Note | For research use only. |
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