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| カタログ番号 | HV281014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-FN3K Polyclonal Antibody (HV281014) is a rabbit polyclonal antibody detecting FN3K in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FN3K (Met1-Lys309). | ||||||||
| ターゲット | Protein-ribulosamine 3-kinase FN3K, Protein-psicosamine 3-kinase FN3K, FN3K, Fructosamine-3-kinase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H479 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Fructosamine-3-kinase (FN3K) is a ~35 kDa protein. Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines. 1. Delpierre, G. et al. (2000) Diabetes 49, 1627-34. PMID: 11016445 2. Szwergold, BS. et al. (2001) Diabetes 50, 2139-47. PMID: 11522682 3. Delpierre, G. et al. (2002) The Biochemical journal 365, 801-8. PMID: 11975663 4. Collard, F. et al. (2003) Diabetes 52, 2888-95. PMID: 14633848 | ||||||||
| 注意事項 | For research use only. |
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