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Anti-FOXK1 Polyclonal Antibody (HB309014)

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Vista general
Número de catálogoHB309014
Descripción
Anti-FOXK1 Polyclonal Antibody (HB309014) is a rabbit polyclonal antibody detecting Forkhead box protein K1; Myocyte nuclear factor; MNF; FOXK1; MNF in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human FOXK1 (Ala86-Arg395).
Objetivo Forkhead box protein K1; Myocyte nuclear factor; MNF; FOXK1; MNF
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P85037, P42128
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Forkhead box protein K1 (FOXK1) is a ~75 kDa protein. Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4. Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate.

1. Freddie, CT. et al. (2007) Nucleic acids research 35, 5203-12. PMID: 17670796
2. Wang, W. et al. (2015) Developmental cell 32, 707-18. PMID: 25805136
3. Panda, D. et al. (2015) mBio 6. PMID: 25852164
4. Baymaz, HI. et al. (2014) Proteomics 14, 2179-89. PMID: 24634419
5. Campagne, A. et al. (2019) Nature communications 10, 348. PMID: 30664650
6. Zhang, HL. et al. (2025) Nature chemical biology 21, 1531-1543. PMID: 40246981
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-FOXK1 Polyclonal Antibody

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