Anti-FOXK1 Polyclonal Antibody (HB309014)

Name: Anti-FOXK1 Polyclonal Antibody
Brand: abinScience
SKU: HB309014
Price: 168 USD
Availability: InStock

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50ug
100ug

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SDS

Aperçu

Numéro de catalogue

HB309014

Description

Anti-FOXK1 Polyclonal Antibody (HB309014) is a rabbit polyclonal antibody detecting Forkhead box protein K1; Myocyte nuclear factor; MNF; FOXK1; MNF in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant human FOXK1 (Ala86-Arg395).

Cible

Forkhead box protein K1; Myocyte nuclear factor; MNF; FOXK1; MNF

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

P85037, P42128

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Forkhead box protein K1 (FOXK1) is a ~75 kDa protein. Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4. Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate.

1. Freddie, CT. et al. (2007) Nucleic acids research 35, 5203-12. PMID: 17670796

2. Wang, W. et al. (2015) Developmental cell 32, 707-18. PMID: 25805136

3. Panda, D. et al. (2015) mBio 6. PMID: 25852164

4. Baymaz, HI. et al. (2014) Proteomics 14, 2179-89. PMID: 24634419

5. Campagne, A. et al. (2019) Nature communications 10, 348. PMID: 30664650

6. Zhang, HL. et al. (2025) Nature chemical biology 21, 1531-1543. PMID: 40246981

Note

For research use only

Images

Reférences

Fiche technique

Anti-FOXK1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-FOXK1 Polyclonal Antibody (HB309014)

Aperçu

Images

Reférences

Fiche technique

SDS