Anti-FOXK1 Polyclonal Antibody (HB309014)

Name: Anti-FOXK1 Polyclonal Antibody
Brand: abinScience
SKU: HB309014
Price: 168 USD
Availability: InStock

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Каталожный номер

HB309014

Описание

Anti-FOXK1 Polyclonal Antibody (HB309014) is a rabbit polyclonal antibody detecting Forkhead box protein K1; Myocyte nuclear factor; MNF; FOXK1; MNF in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human FOXK1 (Ala86-Arg395).

Цель

Forkhead box protein K1; Myocyte nuclear factor; MNF; FOXK1; MNF

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

P85037, P42128

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Forkhead box protein K1 (FOXK1) is a ~75 kDa protein. Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4. Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate.

1. Freddie, CT. et al. (2007) Nucleic acids research 35, 5203-12. PMID: 17670796

2. Wang, W. et al. (2015) Developmental cell 32, 707-18. PMID: 25805136

3. Panda, D. et al. (2015) mBio 6. PMID: 25852164

4. Baymaz, HI. et al. (2014) Proteomics 14, 2179-89. PMID: 24634419

5. Campagne, A. et al. (2019) Nature communications 10, 348. PMID: 30664650

6. Zhang, HL. et al. (2025) Nature chemical biology 21, 1531-1543. PMID: 40246981

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-FOXK1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

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Anti-FOXK1 Polyclonal Antibody (HB309014)

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