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| カタログ番号 | HB008014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-FPR1 Polyclonal Antibody (HB008014) is a rabbit polyclonal antibody detecting FPR1 in ELISA, IHC, WB. Suitable for Human, Pan troglodytes, and Pongo pygmaeus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FPR1 (Arg163-Val242). | ||||||||
| ターゲット | fMet-Leu-Phe receptor, fMLP receptor, N-formyl peptide receptor, FPR, FPR1, N-formylpeptide chemoattractant receptor | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P21462 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | N-formyl peptide receptor 1 (FPR1) is a ~38 kDa protein. Pattern recognition G-protein coupled receptor (PRR/GPCR) involved in innate recognition of N-formyl-methionyl peptides derived from invading microbes and host mitochondria as pathogen- and damage-associated molecular patterns (PAMPs and DAMPs). Functions as a sensor of PAMPs and DAMPs released upon microbial infection or tissue damage, triggering immune cell activation and chemotaxis to eliminate pathogens and restore tissue homeostasis. Peptide binding leads to conformational changes coupled to heterotrimeric G(i) protein signaling. Upon GDP to GTP conversion, G(i)-alpha subunit dissociates from G-beta and G-gamma subunits. Free G(i)-alpha subunit inhibits cyclic adenylate cyclase and cAMP synthesis whereas the G-beta and G-gamma dimer activates downstream phospholipase C-beta and phosphoinositide 3-kinase signaling cascades leading to Ca(2+) influx. 1. Cooray, SN. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 18232-7. PMID: 24108355 2. Bufe, B. et al. (2015) The Journal of biological chemistry 290, 7369-87. PMID: 25605714 3. Zhuang, Y. et al. (2022) Nature communications 13, 1054. PMID: 35217703 4. Chen, G. et al. (2022) Nature communications 13, 5232. PMID: 36064945 5. Maestes, DC. et al. (1999) The Journal of biological chemistry 274, 29791-5. PMID: 10514456 6. Postma, B. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 6994-7001. PMID: 15153520 7. Murphy, PM. et al. (1991) The Journal of biological chemistry 266, 12560-7. PMID: 1712023 | ||||||||
| 注意事項 | For research use only. |
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