

| Número de catálogo | HB210014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-FST Polyclonal Antibody (HB210014) is a rabbit polyclonal antibody detecting FST/Follistatin in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Reactividad de especies | Human, Mouse, Rat | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human FST (Arg35-Val283). | ||||||||
| Objetivo | Activin-binding protein, FS, FST, Follistatin | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P19883 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Follistatin (FST) is a ~38 kDa protein. Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling. Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin. Also promotes neural differentiation by antagonizing the action BMP4. Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA. 1. Sidis, Y. et al. (2001) The Journal of biological chemistry 276, 17718-26. PMID: 11279126 2. Harrington, AE. et al. (2006) The EMBO journal 25, 1035-45. PMID: 16482217 3. Schneyer, AL. et al. (2008) Endocrinology 149, 4589-95. PMID: 18535106 | ||||||||
| Nota | For research use only. |



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