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| カタログ番号 | HB210014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-FST Polyclonal Antibody (HB210014) is a rabbit polyclonal antibody detecting FST/Follistatin in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FST (Arg35-Val283). | ||||||||
| ターゲット | Activin-binding protein, FS, FST, Follistatin | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P19883 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Follistatin (FST) is a ~38 kDa protein. Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling. Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin. Also promotes neural differentiation by antagonizing the action BMP4. Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA. 1. Sidis, Y. et al. (2001) The Journal of biological chemistry 276, 17718-26. PMID: 11279126 2. Harrington, AE. et al. (2006) The EMBO journal 25, 1035-45. PMID: 16482217 3. Schneyer, AL. et al. (2008) Endocrinology 149, 4589-95. PMID: 18535106 | ||||||||
| 注意事項 | For research use only. |
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