Anti-FUT2 Polyclonal Antibody (HC418014)

Name: Anti-FUT2 Polyclonal Antibody
Brand: abinScience
SKU: HC418014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HC418014

Description

Anti-FUT2 Polyclonal Antibody (HC418014) is a rabbit polyclonal antibody detecting FUT2 in ELISA, IHC, WB. Suitable for Human, Hylobates lar, Pan troglodytes, and Pongo pygmaeus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human FUT2 (Gln29-His343).

Cible

Fucosyltransferase 2, SE2, Se, Galactoside alpha-(1, 2)-fucosyltransferase 2, Secretor blood group alpha-2-fucosyltransferase, Alpha(1, 2)FT 2, Type 1 galactoside alpha-(1, 2)-fucosyltransferase FUT2, FUT2, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, Type 2 galactoside alpha-(1, 2)-fucosyltransferase FUT2, Secretor factor, SEC2

Purification

Purified by antigen affinity column.

Numéro d'accès

Q10981

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Galactoside alpha-(1,2)-fucosyltransferase 2 (FUT2) is a ~39 kDa protein. Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation. Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway.

1. Lindesmith, L. et al. (2003) Nature medicine 9, 548-53. PMID: 12692541

2. Kelly, RJ. et al. (1995) The Journal of biological chemistry 270, 4640-9. PMID: 7876235

3. Borén, T. et al. (1993) Science (New York, N.Y.) 262, 1892-5. PMID: 8018146

4. Wacklin, P. et al. (2011) PloS one 6, e20113. PMID: 21625510

5. Rausch, P. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 19030-5. PMID: 22068912

6. Wacklin, P. et al. (2014) PloS one 9, e94863. PMID: 24733310

Note

For research use only.

Images

Reférences

Fiche technique

Anti-FUT2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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