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| カタログ番号 | HC418014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-FUT2 Polyclonal Antibody (HC418014) is a rabbit polyclonal antibody detecting FUT2 in ELISA, IHC, WB. Suitable for Human, Hylobates lar, Pan troglodytes, and Pongo pygmaeus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FUT2 (Gln29-His343). | ||||||||
| ターゲット | Fucosyltransferase 2, SE2, Se, Galactoside alpha-(1, 2)-fucosyltransferase 2, Secretor blood group alpha-2-fucosyltransferase, Alpha(1, 2)FT 2, Type 1 galactoside alpha-(1, 2)-fucosyltransferase FUT2, FUT2, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, Type 2 galactoside alpha-(1, 2)-fucosyltransferase FUT2, Secretor factor, SEC2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q10981 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Galactoside alpha-(1,2)-fucosyltransferase 2 (FUT2) is a ~39 kDa protein. Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation. Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway. 1. Lindesmith, L. et al. (2003) Nature medicine 9, 548-53. PMID: 12692541 2. Kelly, RJ. et al. (1995) The Journal of biological chemistry 270, 4640-9. PMID: 7876235 3. Borén, T. et al. (1993) Science (New York, N.Y.) 262, 1892-5. PMID: 8018146 4. Wacklin, P. et al. (2011) PloS one 6, e20113. PMID: 21625510 5. Rausch, P. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 19030-5. PMID: 22068912 6. Wacklin, P. et al. (2014) PloS one 9, e94863. PMID: 24733310 | ||||||||
| 注意事項 | For research use only. |
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