Anti-Human GABRA5 Polyclonal Antibody (HB780014)

Name: Anti-Human GABRA5 Polyclonal Antibody
Brand: abinScience
SKU: HB780014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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Datasheet
SDS

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Número de catálogo

HB780014

Descripción

Anti-GABRA5 Polyclonal Antibody (HB780014) is a rabbit polyclonal antibody detecting Gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor subunit alpha-5; GABRA5 in ELISA, IHC, WB. Suitable for Human, Rat, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant human GABRA5 (Gln32-Tyr259).

Objetivo

Gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor subunit alpha-5; GABRA5

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P31644, P19969, Q8BHJ7, Q08E50

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) is a ~52 kDa protein. Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus. Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes.

1. Caraiscos, VB. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 3662-7. PMID: 14993607

2. Butler, KM. et al. (2018) Brain : a journal of neurology 141, 2392-2405. PMID: 29961870

3. Liu, S. et al. (2018) Cell research 28, 958-961. PMID: 30140029

4. Hernandez, CC. et al. (2019) Brain : a journal of neurology 142, 1938-1954. PMID: 31056671

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human GABRA5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human GABRA5 Polyclonal Antibody (HB780014)

Vista general

Imágenes

Referencias

Datasheet

SDS