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| カタログ番号 | HW374014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GDF5 Polyclonal Antibody (HW374014) is a rabbit polyclonal antibody detecting GDF5 in ELISA, IHC, WB. Suitable for Mouse and Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GDF5 (Ala382-Arg501). | ||||||||
| ターゲット | Growth/differentiation factor 5, BMP14, BMP-14, Radotermin, GDF-5, Bone morphogenetic protein 14, GDF5, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, CDMP1, Cartilage-derived morphogenetic protein 1, LPS-associated protein 4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P43026 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Growth/differentiation factor 5 (GDF5) is a ~55 kDa protein. Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. 1. Bai, X. et al. (2004) Biochemical and biophysical research communications 325, 453-60. PMID: 15530414 2. Schwaerzer, GK. et al. (2012) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 27, 429-42. PMID: 21976273 3. Degenkolbe, E. et al. (2013) PLoS genetics 9, e1003846. PMID: 24098149 4. Stange, K. et al. (2014) Journal of molecular biology 426, 3221-3231. PMID: 25092592 5. Triantafilou, K. et al. (2001) Nature immunology 2, 338-45. PMID: 11276205 | ||||||||
| 注意事項 | For research use only. |
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