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Anti-GGT5 Polyclonal Antibody (HW691014)

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Aperçu
Numéro de catalogueHW691014
Description
Anti-GGT5 Polyclonal Antibody (HW691014) is a rabbit polyclonal antibody detecting GGT5 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human GGT5 (Thr388-Tyr586).
Cible GGTLA1, Gamma-glutamyl transpeptidase-related enzyme, Gamma-glutamyltranspeptidase 5, Glutathione hydrolase 5 proenzyme, GGT 5, Gamma-glutamyltransferase 5, GGT5, Leukotriene-C4 hydrolase, Gamma-glutamyltransferase-like activity 1, GGT-rel
Purification Purified by antigen affinity column.
Numéro d'accès P36269
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Glutathione hydrolase 5 proenzyme (GGT5) is a ~62 kDa protein. Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates. Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis. Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine. Converts extracellular LTC4 to LTD4 during acute inflammatory response. Acts as a negative regulator of GGG bioactivity.

1. Heisterkamp, N. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 6303-7. PMID: 1676842
2. Wickham, S. et al. (2011) Analytical biochemistry 414, 208-14. PMID: 21447318
3. Bachhawat, AK. et al. (2018) IUBMB life 70, 585-592. PMID: 29667297
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-GGT5 Polyclonal Antibody

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