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| カタログ番号 | HW691014 | ||||||||
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| 説明 |
Anti-GGT5 Polyclonal Antibody (HW691014) is a rabbit polyclonal antibody detecting GGT5 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GGT5 (Thr388-Tyr586). | ||||||||
| ターゲット | GGTLA1, Gamma-glutamyl transpeptidase-related enzyme, Gamma-glutamyltranspeptidase 5, Glutathione hydrolase 5 proenzyme, GGT 5, Gamma-glutamyltransferase 5, GGT5, Leukotriene-C4 hydrolase, Gamma-glutamyltransferase-like activity 1, GGT-rel | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P36269 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Glutathione hydrolase 5 proenzyme (GGT5) is a ~62 kDa protein. Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates. Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis. Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine. Converts extracellular LTC4 to LTD4 during acute inflammatory response. Acts as a negative regulator of GGG bioactivity. 1. Heisterkamp, N. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 6303-7. PMID: 1676842 2. Wickham, S. et al. (2011) Analytical biochemistry 414, 208-14. PMID: 21447318 3. Bachhawat, AK. et al. (2018) IUBMB life 70, 585-592. PMID: 29667297 | ||||||||
| 注意事項 | For research use only. |
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