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Anti-Human GLP-1R Polyclonal Antibody (HW328014)

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概要
カタログ番号HW328014
説明
Anti-GLP1R Polyclonal Antibody (HW328014) is a rabbit polyclonal antibody detecting GLP1R in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
種反応性Human
アプリケーションELISA, IHC, WB
宿主種Rabbit
クローン性Polyclonal
アイソタイプIgG
免疫原 E. coli - derived recombinant Human GLP1R (Arg24-Tyr145).
ターゲット GLP-1 receptor, Glucagon-like peptide 1 receptor, GLP1R, GLP-1-R, GLP-1R
精製 Purified by antigen affinity column.
アクセッション番号 P43220
形態 Liquid
保存バッファー 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報
アプリケーション 希釈
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
安定性と保存 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Glucagon-like peptide 1 receptor (GLP1R) is a ~53 kDa protein. G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1.

1. Underwood, CR. et al. (2010) The Journal of biological chemistry 285, 723-30. PMID: 19861722
2. Lau, J. et al. (2015) Journal of medicinal chemistry 58, 7370-80. PMID: 26308095
3. Hennen, S. et al. (2016) Scientific reports 6, 26236. PMID: 27196125
4. Song, G. et al. (2017) Nature 546, 312-315. PMID: 28514449
5. van Eyll, B. et al. (1994) FEBS letters 348, 7-13. PMID: 7517895
6. Graziano, MP. et al. (1993) Biochemical and biophysical research communications 196, 141-6. PMID: 8216285
7. Thorens, B. et al. (1993) Diabetes 42, 1678-82. PMID: 8405712
注意事項 For research use only.
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参考文献
Formula
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