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| カタログ番号 | HF524014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GLRX3 Polyclonal Antibody (HF524014) is a rabbit polyclonal antibody detecting GLRX3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GLRX3 (Val10-Ser117). | ||||||||
| ターゲット | PKCq-interacting protein, PKC-theta-interacting protein, Glutaredoxin-3, PKC-interacting cousin of thioredoxin, PICOT, GLRX3, Thioredoxin-like protein 2, TXNL2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O76003 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Glutaredoxin-3 (GLRX3) is a ~37 kDa protein. Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. 1. Banci, L. et al. (2015) Journal of the American Chemical Society 137, 16133-43. PMID: 26613676 2. Frey, AG. et al. (2016) The Journal of biological chemistry 291, 22344-22356. PMID: 27519415 3. Haunhorst, P. et al. (2013) Molecular biology of the cell 24, 1895-903. PMID: 23615448 | ||||||||
| 注意事項 | For research use only. |
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