

| Numéro de catalogue | HF969014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-GMNN Polyclonal Antibody (HF969014) is a rabbit polyclonal antibody detecting GMNN in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human GMNN (Met1-Ile209). | ||||||||
| Cible | Geminin, GMNN | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O75496 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Geminin (GMNN) is a ~23 kDa protein. Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control. 1. Sugimoto, N. et al. (2004) The Journal of biological chemistry 279, 19691-7. PMID: 14993212 2. Miotto, B. et al. (2010) Molecular cell 37, 57-66. PMID: 20129055 3. Caillat, C. et al. (2013) The Journal of biological chemistry 288, 31624-34. PMID: 24064211 4. McGarry, TJ. et al. (1998) Cell 93, 1043-53. PMID: 9635433 | ||||||||
| Note | For research use only. |
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