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| カタログ番号 | HF969014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GMNN Polyclonal Antibody (HF969014) is a rabbit polyclonal antibody detecting GMNN in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GMNN (Met1-Ile209). | ||||||||
| ターゲット | Geminin, GMNN | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75496 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Geminin (GMNN) is a ~23 kDa protein. Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control. 1. Sugimoto, N. et al. (2004) The Journal of biological chemistry 279, 19691-7. PMID: 14993212 2. Miotto, B. et al. (2010) Molecular cell 37, 57-66. PMID: 20129055 3. Caillat, C. et al. (2013) The Journal of biological chemistry 288, 31624-34. PMID: 24064211 4. McGarry, TJ. et al. (1998) Cell 93, 1043-53. PMID: 9635433 | ||||||||
| 注意事項 | For research use only. |
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