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| カタログ番号 | HB520014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GNA13 Polyclonal Antibody (HB520014) is a rabbit polyclonal antibody detecting Guanine nucleotide-binding protein subunit alpha-13; G alpha-13; G-protein subunit alpha-13; GNA13 in ELISA, IHC, WB. Suitable for Human, Rat, and Mouse.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human GNA13 (Leu48-Gln377). | ||||||||
| ターゲット | Guanine nucleotide-binding protein subunit alpha-13; G alpha-13; G-protein subunit alpha-13; GNA13 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q14344, Q6Q7Y5, P27601 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Guanine nucleotide-binding protein subunit alpha-13 (GNA13) is a ~44 kDa protein. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in a process independent from Rho activation. 1. Krakstad, BF. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 10314-9. PMID: 15240885 2. Kelly, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 8173-8. PMID: 16705036 3. Kelly, P. et al. (2006) The Journal of biological chemistry 281, 26483-90. PMID: 16787920 4. Yuan, B. et al. (2016) Biochemical and biophysical research communications 473, 1240-1246. PMID: 27084452 5. Suzuki, N. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 733-8. PMID: 12515866 6. Meigs, TE. et al. (2002) The Journal of biological chemistry 277, 24594-600. PMID: 11976333 | ||||||||
| 注意事項 | For research use only |
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