Anti-GNA13 Polyclonal Antibody (HB520014)

Name: Anti-GNA13 Polyclonal Antibody
Brand: abinScience
SKU: HB520014
Price: 168 USD
Availability: InStock

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Каталожный номер

HB520014

Описание

Anti-GNA13 Polyclonal Antibody (HB520014) is a rabbit polyclonal antibody detecting Guanine nucleotide-binding protein subunit alpha-13; G alpha-13; G-protein subunit alpha-13; GNA13 in ELISA, IHC, WB. Suitable for Human, Rat, and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human GNA13 (Leu48-Gln377).

Цель

Guanine nucleotide-binding protein subunit alpha-13; G alpha-13; G-protein subunit alpha-13; GNA13

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

Q14344, Q6Q7Y5, P27601

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Guanine nucleotide-binding protein subunit alpha-13 (GNA13) is a ~44 kDa protein. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in a process independent from Rho activation.

1. Krakstad, BF. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 10314-9. PMID: 15240885

2. Kelly, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 8173-8. PMID: 16705036

3. Kelly, P. et al. (2006) The Journal of biological chemistry 281, 26483-90. PMID: 16787920

4. Yuan, B. et al. (2016) Biochemical and biophysical research communications 473, 1240-1246. PMID: 27084452

5. Suzuki, N. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 733-8. PMID: 12515866

6. Meigs, TE. et al. (2002) The Journal of biological chemistry 277, 24594-600. PMID: 11976333

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-GNA13 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-GNA13 Polyclonal Antibody (HB520014)

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