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| カタログ番号 | HB595014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GNAI2 Polyclonal Antibody (HB595014) is a rabbit polyclonal antibody detecting Guanine nucleotide-binding protein G(i) subunit alpha-2; Adenylate cyclase-inhibiting G alpha protein; GNAI2; GNAI2B in ELISA, IHC, WB. Suitable for Human, Rat, Mouse, Dog, and Chicken.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human GNAI2 (Ala31-Phe355). | ||||||||
| ターゲット | Guanine nucleotide-binding protein G(i) subunit alpha-2; Adenylate cyclase-inhibiting G alpha protein; GNAI2; GNAI2B | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P04899, P04897, P08752, P38400, P50147, P10824, P63096, P63097, B2RSH2, P50146, P27044, P08754 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) is a ~40 kDa protein. Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. Examples of interacting GPCRs include the adenosine A1 receptor/ADORA1, CNR1, and FPR2. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. 1. Bai, CW. et al. (2024) Theranostics 14, 2190-2209. PMID: 38505600 2. Draper-Joyce, CJ. et al. (2018) Nature 558, 559-563. PMID: 29925945 3. Yang, X. et al. (2022) Nature chemical biology 18, 831-840. PMID: 35637350 4. Zhu, Y. et al. (2022) Nature communications 13, 1775. PMID: 35365641 5. Komatsuzaki, K. et al. (2002) Biochemical and biophysical research communications 297, 898-905. PMID: 12359238 | ||||||||
| 注意事項 | For research use only |
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