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| カタログ番号 | HY491014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GPI Polyclonal Antibody (HY491014) is a rabbit polyclonal antibody detecting GPI in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GPI (Met263-Asn475). | ||||||||
| ターゲット | GPI, NLK, Neuroleukin, Phosphohexose isomerase, PHI, Sperm antigen 36, Autocrine motility factor, AMF, SA-36, PGI, Glucose-6-phosphate isomerase, Phosphoglucose isomerase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P06744 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Glucose-6-phosphate isomerase (GPI) is a ~63 kDa protein. Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm. Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P. In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility. Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons. 1. Mojzikova, R. et al. (2018) Blood cells, molecules & diseases 69, 23-29. PMID: 28803808 2. Funasaka, T. et al. (2001) Biochemical and biophysical research communications 285, 118-28. PMID: 11437381 3. Haga, A. et al. (2000) Biochimica et biophysica acta 1480, 235-44. PMID: 11004567 4. Faik, P. et al. (1988) Nature 332, 455-7. PMID: 3352745 | ||||||||
| 注意事項 | For research use only. |
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