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Anti-GPR68 Polyclonal Antibody (HS932014)

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Aperçu
Numéro de catalogueHS932014
Description
Anti-GPR68 Polyclonal Antibody (HS932014) is a rabbit polyclonal antibody detecting Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor; GPR68; OGR1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant human GPR68 (Leu285-Ala365).
Cible Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor; GPR68; OGR1
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès Q15743, Q8BFQ3
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

G-protein coupled receptor 68 (GPR68) is a ~41 kDa protein. Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Acts as a key mechanosensor of fluid shear stress and membrane stretch.

1. Ludwig, MG. et al. (2003) Nature 425, 93-8. PMID: 12955148
2. Xu, J. et al. (2018) Cell 173, 762-775.e16. PMID: 29677517
3. Huang, XP. et al. (2020) Biochemistry 59, 3594-3614. PMID: 32865988
4. Rowe, JB. et al. (2021) The Journal of biological chemistry 296, 100167. PMID: 33478938
5. Howard, MK. et al. (2025) Cell 188, 671-687.e20. PMID: 39753132
6. Guo, L. et al. (2025) Molecular cell 85, 1658-1673.e7. PMID: 40215959
7. Chen, LN. et al. (2025) Molecular cell 85, 1640-1657.e8. PMID: 40215960
Note For research use only
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Formula
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Anti-GPR68 Polyclonal Antibody

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