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| カタログ番号 | HS932014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GPR68 Polyclonal Antibody (HS932014) is a rabbit polyclonal antibody detecting Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor; GPR68; OGR1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human GPR68 (Leu285-Ala365). | ||||||||
| ターゲット | Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor; GPR68; OGR1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15743, Q8BFQ3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | G-protein coupled receptor 68 (GPR68) is a ~41 kDa protein. Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Acts as a key mechanosensor of fluid shear stress and membrane stretch. 1. Ludwig, MG. et al. (2003) Nature 425, 93-8. PMID: 12955148 2. Xu, J. et al. (2018) Cell 173, 762-775.e16. PMID: 29677517 3. Huang, XP. et al. (2020) Biochemistry 59, 3594-3614. PMID: 32865988 4. Rowe, JB. et al. (2021) The Journal of biological chemistry 296, 100167. PMID: 33478938 5. Howard, MK. et al. (2025) Cell 188, 671-687.e20. PMID: 39753132 6. Guo, L. et al. (2025) Molecular cell 85, 1658-1673.e7. PMID: 40215959 7. Chen, LN. et al. (2025) Molecular cell 85, 1640-1657.e8. PMID: 40215960 | ||||||||
| 注意事項 | For research use only |
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