Anti-GPR68 Polyclonal Antibody (HS932014)

Name: Anti-GPR68 Polyclonal Antibody
Brand: abinScience
SKU: HS932014
Price: 168 USD
Availability: InStock

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Каталожный номер

HS932014

Описание

Anti-GPR68 Polyclonal Antibody (HS932014) is a rabbit polyclonal antibody detecting Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor; GPR68; OGR1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human GPR68 (Leu285-Ala365).

Цель

Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor; GPR68; OGR1

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

Q15743, Q8BFQ3

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

G-protein coupled receptor 68 (GPR68) is a ~41 kDa protein. Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Acts as a key mechanosensor of fluid shear stress and membrane stretch.

1. Ludwig, MG. et al. (2003) Nature 425, 93-8. PMID: 12955148

2. Xu, J. et al. (2018) Cell 173, 762-775.e16. PMID: 29677517

3. Huang, XP. et al. (2020) Biochemistry 59, 3594-3614. PMID: 32865988

4. Rowe, JB. et al. (2021) The Journal of biological chemistry 296, 100167. PMID: 33478938

5. Howard, MK. et al. (2025) Cell 188, 671-687.e20. PMID: 39753132

6. Guo, L. et al. (2025) Molecular cell 85, 1658-1673.e7. PMID: 40215959

7. Chen, LN. et al. (2025) Molecular cell 85, 1640-1657.e8. PMID: 40215960

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-GPR68 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-GPR68 Polyclonal Antibody (HS932014)

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