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| カタログ番号 | HC657014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GRIN2A Polyclonal Antibody (HC657014) is a rabbit polyclonal antibody detecting GRIN2A in ELISA, IHC, WB. Suitable for Human, Mouse, Pan troglodytes, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GRIN2A (Pro23-Ala555). | ||||||||
| ターゲット | N-methyl D-aspartate receptor subtype 2A, NMDAR2A, Glutamate [NMDA] receptor subunit epsilon-1, hNR2A, NR2A, Glutamate receptor ionotropic, NMDA 2A, GRIN2A, GluN2A | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q12879 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Glutamate receptor ionotropic, NMDA 2A (GRIN2A) is a ~165 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. 1. Endele, S. et al. (2010) Nature genetics 42, 1021-6. PMID: 20890276 2. Carvill, GL. et al. (2013) Nature genetics 45, 1073-6. PMID: 23933818 3. Lemke, JR. et al. (2013) Nature genetics 45, 1067-72. PMID: 23933819 4. Lesca, G. et al. (2013) Nature genetics 45, 1061-6. PMID: 23933820 5. Yuan, H. et al. (2014) Nature communications 5, 3251. PMID: 24504326 6. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626 7. Volgraf, M. et al. (2016) Journal of medicinal chemistry 59, 2760-79. PMID: 26919761 8. Addis, L. et al. (2017) Scientific reports 7, 66. PMID: 28242877 9. Iacobucci, GJ. et al. (2022) Molecular psychiatry 27, 5113-5123. PMID: 36117210 10. Xu, Y. et al. (2024) Cellular and molecular life sciences : CMLS 81, 153. PMID: 38538865 | ||||||||
| 注意事項 | For research use only. |
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