| Цель |
N-methyl D-aspartate receptor subtype 2A, NMDAR2A, Glutamate [NMDA] receptor subunit epsilon-1, hNR2A, NR2A, Glutamate receptor ionotropic, NMDA 2A, GRIN2A, GluN2A |
| Буфер хранения |
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
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| Фон | Glutamate receptor ionotropic, NMDA 2A (GRIN2A) is a ~165 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. 1. Endele, S. et al. (2010) Nature genetics 42, 1021-6. PMID: 208902762. Carvill, GL. et al. (2013) Nature genetics 45, 1073-6. PMID: 239338183. Lemke, JR. et al. (2013) Nature genetics 45, 1067-72. PMID: 239338195. Yuan, H. et al. (2014) Nature communications 5, 3251. PMID: 245043267. Volgraf, M. et al. (2016) Journal of medicinal chemistry 59, 2760-79. PMID: 269197619. Iacobucci, GJ. et al. (2022) Molecular psychiatry 27, 5113-5123. PMID: 3611721010. Xu, Y. et al. (2024) Cellular and molecular life sciences : CMLS 81, 153. PMID: 38538865 |
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