Anti-GRIN2A Polyclonal Antibody (HC657024) is a rabbit polyclonal antibody detecting GRIN2A in ELISA, IHC, WB. Suitable for Human, Mouse, Pan troglodytes, Rat, and Xenopus laevis.
Highlights
●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.
Reactividad de especies
Human, Mouse, Rat
Aplicaciones
ELISA, IHC, WB
Especie huésped
Rabbit
Clonalidad
Polyclonal
Isotipo
IgG
Inmunógeno
E. coli - derived recombinant Human GRIN2A (Pro401-Arg539).
Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación
Dilución
ELISA
1:5000-1:20000
IHC
1:50-1:500
WB
1:500-1:2000
Estabilidad y almacenamiento
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo
Glutamate receptor ionotropic, NMDA 2A (GRIN2A) is a ~165 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.
1. Endele, S. et al. (2010) Nature genetics 42, 1021-6. PMID: 20890276
中文
English
한국어
日本語
Español
Français
Русский
