Anti-GRIN2A Polyclonal Antibody (HC657024) is a rabbit polyclonal antibody detecting GRIN2A in ELISA, IHC, WB. Suitable for Human, Mouse, Pan troglodytes, Rat, and Xenopus laevis.
Highlights
●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.
Реактивность видов
Human, Mouse, Rat
Применения
ELISA, IHC, WB
Хозяинский вид
Rabbit
Клоональность
Polyclonal
Изотип
IgG
Иммуноген
E. coli - derived recombinant Human GRIN2A (Pro401-Arg539).
Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Информация об использовании продукта
Применение
Разбавление
ELISA
1:5000-1:20000
IHC
1:50-1:500
WB
1:500-1:2000
Устойчивость и хранение
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон
Glutamate receptor ionotropic, NMDA 2A (GRIN2A) is a ~165 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.
1. Endele, S. et al. (2010) Nature genetics 42, 1021-6. PMID: 20890276
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