Anti-GRIN2B Polyclonal Antibody (HC330014)

Name: Anti-GRIN2B Polyclonal Antibody
Brand: abinScience
SKU: HC330014
Price: 96 USD
Availability: InStock

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HC330014

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human GRIN2B (Tyr1133-Val1484).

Цель

GluN2B, Glutamate receptor ionotropic, NMDA 2B, GRIN2B, NMDAR2B, NR2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl-D-aspartate receptor subunit 3, N-methyl D-aspartate receptor subtype 2B, hNR3, NR3

Очистка

Purified by antigen affinity column.

Номер доступа

Q13224

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Glutamate receptor ionotropic, NMDA 2B (GRIN2B) is a ~166 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.

1. Lemke, JR. et al. (2014) Annals of neurology 75, 147-54. PMID: 24272827

2. Adams, DR. et al. (2014) Molecular genetics and metabolism 113, 161-70. PMID: 24863970

3. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626

4. Volgraf, M. et al. (2016) Journal of medicinal chemistry 59, 2760-79. PMID: 26919761

5. Swanger, SA. et al. (2016) American journal of human genetics 99, 1261-1280. PMID: 27839871

6. Ogden, KK. et al. (2017) PLoS genetics 13, e1006536. PMID: 28095420

7. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851

8. Xu, Y. et al. (2024) Cellular and molecular life sciences : CMLS 81, 153. PMID: 38538865

9. Hess, SD. et al. (1996) The Journal of pharmacology and experimental therapeutics 278, 808-16. PMID: 8768735

Примечание

For research use only.

Изображения

Western blot

Western blot analysis was performed using anti-GRIN2B polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse brain lysate
Lane 2: Rat brain lysate

Ссылки

Даташит

Anti-GRIN2B Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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