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Anti-GSK3A Polyclonal Antibody (HW600014)

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Número de catálogoHW600014
Descripción
Anti-GSK3A Polyclonal Antibody (HW600014) is a rabbit polyclonal antibody detecting GSK3A in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human GSK3A (Lys99-Ser483).
Objetivo GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinase GSK3A
Purificación Purified by antigen affinity column.
Número de acceso P49840
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Glycogen synthase kinase-3 alpha (GSK3A) is a ~50 kDa protein. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors.

1. Ali, A. et al. (2001) Chemical reviews 101, 2527-40. PMID: 11749387
2. Lee, J. et al. (2007) Diabetes research and clinical practice 77 Suppl 1, S49-57. PMID: 17478001
3. Rayasam, GV. et al. (2009) British journal of pharmacology 156, 885-98. PMID: 19366350
4. Nikoulina, SE. et al. (2000) Diabetes 49, 263-71. PMID: 10868943
Nota For research use only.
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Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-GSK3A Polyclonal Antibody

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