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| カタログ番号 | HW600014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GSK3A Polyclonal Antibody (HW600014) is a rabbit polyclonal antibody detecting GSK3A in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GSK3A (Lys99-Ser483). | ||||||||
| ターゲット | GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinase GSK3A | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P49840 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Glycogen synthase kinase-3 alpha (GSK3A) is a ~50 kDa protein. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. 1. Ali, A. et al. (2001) Chemical reviews 101, 2527-40. PMID: 11749387 2. Lee, J. et al. (2007) Diabetes research and clinical practice 77 Suppl 1, S49-57. PMID: 17478001 3. Rayasam, GV. et al. (2009) British journal of pharmacology 156, 885-98. PMID: 19366350 4. Nikoulina, SE. et al. (2000) Diabetes 49, 263-71. PMID: 10868943 | ||||||||
| 注意事項 | For research use only. |
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