

| Numéro de catalogue | HA643014 | ||||||||
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| Description |
Anti-GUCA1A Polyclonal Antibody (HA643014) is a rabbit polyclonal antibody detecting Guanylyl cyclase-activating protein 1; GCAP 1; Guanylate cyclase activator 1A; GUCA1A; C6orf131; GCAP; GCAP1; GUCA1 in ELISA, IHC, WB. Suitable for Human, Bovine, and Mouse.
Highlights
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| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant human GUCA1A (Met1-Gly201). | ||||||||
| Cible | Guanylyl cyclase-activating protein 1; GCAP 1; Guanylate cyclase activator 1A; GUCA1A; C6orf131; GCAP; GCAP1; GUCA1 | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P43080, P46065, P43081 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Guanylyl cyclase-activating protein 1 (GUCA1A) is a ~22 kDa protein. Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure. May be involved in cone photoreceptor light response and recovery of response in bright light. 1. Jiang, L. et al. (2008) Vision research 48, 2425-32. PMID: 18706439 2. Kitiratschky, VB. et al. (2009) Human mutation 30, E782-96. PMID: 19459154 3. Marino, V. et al. (2018) Human molecular genetics 27, 4204-4217. PMID: 30184081 4. Peshenko, IV. et al. (2019) The Journal of biological chemistry 294, 3476-3488. PMID: 30622141 | ||||||||
| Note | For research use only |
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