Anti-GZMK Polyclonal Antibody (HW458014)

Name: Anti-GZMK Polyclonal Antibody
Brand: abinScience
SKU: HW458014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HW458014

Описание

Anti-GZMK Polyclonal Antibody (HW458014) is a rabbit polyclonal antibody detecting GZMK in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human GZMK (Ile27-Asn264).

Цель

NK-tryptase-2, Fragmentin-3, Granzyme K, GZMK, Granzyme-3, TRYP2, NK-Tryp-2

Очистка

Purified by antigen affinity column.

Номер доступа

P49863

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Granzyme K (GZMK) is a ~28 kDa protein. Serine protease that initiates the GZMK pathway of the complement system, a cascade of proteins directly activated by CD8(+) T-cells that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. GZMK is specifically secreted by CD8(+) T-cells and mediates both recognition and initiation steps of GZMK complement pathway. First acts as a pattern recognition receptor, which specifically recognizes and binds heparan sulfate glycosaminoglycans on the pathogen surface to drive opsonization. It then initiates the complement pathway cascade by catalyzing cleavage and activation of C2 and C4, the next components of the complement pathway. GZMK-mediated complement activation is an important contributor to tissue inflammation.

1. Hameed, A. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 141, 3142-7. PMID: 3262682

2. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882

3. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456

4. Wensink, AC. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 5974-9. PMID: 24711407

5. Mogilenko, DA. et al. (2021) Immunity 54, 99-115.e12. PMID: 33271118

6. Jonsson, AH. et al. (2022) Science translational medicine 14, eabo0686. PMID: 35704599

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-GZMK Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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